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代谢心血管疾病模型

代谢心血管疾病包括2型糖尿病、心脏代谢紊乱、高脂血症、动脉粥样硬化、高血压等，这类慢性病严重影响人的生活质量，并会带来沉重的经济负担。南模生物自主构建了多种代谢心血管疾病模型小鼠，可助力代谢心血管疾病的基础研究和药物开发。

Mouse	R26-CAG-LSL-hSOX2-IRES-Luc-2A-EGFP/Kras-LSL-G12D Strain Name：C57BL/6JSmo-Gt(ROSA)26Sor^{tm(CAG-LSL-SOX2-IRES-Luciferase-2a-EGFP-WPRE-polyA)}Kras^{em4(LSL-G12D)}^Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-234153
Mouse	R26-CAG-LSL-hTM6SF2E167K-EGFP Strain Name：C57BL/6JSmo-Gt(ROSA)26Sor^{tm1(SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA)Smoc}* Strain State：Embryo Cryopreservation \| Cat. NO.：NM-KI-200017 Research Application：Non-alcoholic fatty liver disease
Mouse	R26-CAG-LSL-hTPM3-NTRK1-IRES-Luc-2A-tdTomato Strain Name：C57BL/6JSmo-Gt(ROSA)26Sor^{tm(SA-polyA-CAG-LSL-TPM3-NTRK1-IRES-luc-2A-tdTomato-WPRE-polyA)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-190098 Research Application：Colorectal carcinoma related.
Mouse	R26-CAG-LSL-KrasG12C-IRES-Luc Strain Name：C57BL/6JSmo-Gt(ROSA)26Sor^{em1(CAG-FRT-LSL-Kras(G12C)-IRES-Luciferase-polyA)Smoc}* Strain State：Repository Live \| Cat. NO.：NM-KI-200323
Mouse	R26-CAG-LSL-KrasG12C-IRES-Luc(BALB/c) Strain Name：BALB/cJSmo-Gt(ROSA)26Sor^{em2(CAG-FRT-LSL-Kras(G12C)-IRES-Luciferase-polyA)Smoc}* Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-200324
Mouse	R26-CAG-LSL-Luc-2A-EGFP/Trp53-Flox/Kras-LSL-G12D Strain Name：C57BL/6JSmo-Gt(ROSA)26Sor^{em1(CAG-LSL-Luciferase-2A-EGFP-wpre-polyA)}Trp53^tm2(flox)Kras^{em4(LSL-G12D)}^Smoc Strain State：Embryo Cryopreservation \| Cat. NO.：NM-KI-234519
Mouse	R26-LSL-Notch1C-IRES-nEGFP Strain Name：C57BL/6JSmo-Gt(ROSA)26Sor^{em1(SA-LSL-Notch1C-IRES-nEGFP)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-200036 Research Application：Spontaneous tumor model
Mouse	R26-LSL-SmoM2W539L-IRES-tdTomato Strain Name：C57BL/6JSmo-Gt(ROSA)26Sor^{em1(SA-loxp-stop-loxp-SmoM2(W539L)-IRES-tdTomato-WPRE-polyA)Smoc} Strain State：Embryo Cryopreservation \| Cat. NO.：NM-KI-200035 Research Application：Medulloblastoma
Mouse	Smad4-Flox Strain Name：C57BL/6JSmo-Smad4^{tm1(flox)Smoc} Strain State：Repository Live \| Cat. NO.：NM-CKO-18011 Disease Connection：osteogenesis imperfecta, squamous cell carcinoma, stomach cancer
Mouse	Trp53-Flox Strain Name：C57BL/6JSmo-Trp53^{tm2(flox)Smoc} Strain State：Repository Live \| Cat. NO.：NM-CKO-18005 Disease Connection：medulloblastoma, breast cancer, prostate cancer, central nervous system cancer, osteosarcoma, pancreatic carcinoma, malignant astrocytoma, thyroid gland carcinoma, ovarian cancer, urinary bladder cancer, alveolar rhabdomyosarcoma, glioblastoma, pancreatic ductal adenocarcinoma, squamous cell carcinoma, thyroid gland cancer, CHARGE syndrome, stomach cancer, invasive lobular carcinoma, endometrial cancer, hereditary breast ovarian cancer syndrome, pancreatic mucinous cystadenoma

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