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U-GEMMs

Toolbox of Mice

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Humanized Drug Targets

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Popular Strains

Humanized PD-1 Mice

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Model Customization

Gene Editing Technology

ES Cell Targeting

CRISPR Gene Editing

Transgene

Genetically Engineered Type

Conventional Knockout (KO)

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Point Mutation

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Humanization

Targeted Conditional Overexpression

Random Transgene

Surgery & Preconditioning

Surgery

Preconditioning

Supporting Solutions

Colony Management

Cryopreservation and Cryorecovery

Housing and Management

Genotyping Analysis

Breeding Services

Auxiliary Apparatuses

e-BLOT WB Imaging System
Pre-clinical CRO Services
Oncology Drug Efficacy Evaluation Platform

Syngeneic Models

Genetically Modified Tumor Mouse Models

GMM models of cancer

GMM-derived tumor allograft models

Xenograft mouse models

CDX

PDX

Human Immune System Reconstituted Models

HuPBMC

HuHSC

Metabolism Disease Evaluation Platform

Obesity/Diabetes Models

MASH Model

Other metabolic disease models

Hyperuricemia Models

Atherosclerosis Models

Phenylketonuria Models

Humanized Metabolic Research Model

Inflammation Disease Evaluation Platform

Inflammation/Autoimmune Disease Model

Psoriasis model

Atopic Dermatitis Model

Delayed-type hypersensitivity Model

Androgenetic Alopecia Model

Asthma Model

Pulmonary Fibrosis Model

Rheumatoid Arthritis Model

Osteoarthritis Model

Systemic Lupus Erythematosus Model

Sepsis Model

Multiple Sclerosis Model

Graft-Versus-Host Disease Model

Inflammatory Bowel Disease Model

Chronic Kidney Disease Model

Others immune-mediated inflammatory diseases model

Neurological Disease Evaluation Platform

Neurological Disease Models

Parkinson's Disease Model

Alzheimer's Disease Model

Depression Model

Pain Model

Cerebrovascular Diseases Model

Intracranial Tumor

Amyotrophic Lateral Sclerosis Model

Other Neurological Disease Models

Behavioral Research Platform

Cell Lines Service Platform

Off-the-shelf cell lines

iPSC-mediated Disease Models

Cell Line Customization Services

Ex vivo & In vitro Evaluation Service Platform

Ex vivo Pharmacodynamic Evaluation Service

In vitro Pharmacodynamic Evaluation Service

Toxicology/Pathology Service Platform

Non-GLP Toxicology Evaluation Platform

Pathology Service Platform
Resources & Support
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U-GEMMs

The establishment of U-GEMM (yoUr Genetically Engineered Mouse Model) repository containing 6,000+ “off-shelf” proprietary sets the stage of entry into new possibilities in gene function, drug screening, and human disease research.

Mouse	Spg21-Flox Strain Name：C57BL/6Smoc-Spg21^{em1(flox)Smoc} Strain State：Developing \| Cat. NO.：TBD
Mouse	Spg21-KO Strain Name：C57BL/6Smoc-Spg21^em1Smoc Strain State：Developing \| Cat. NO.：TBD Disease Connection：Mast syndrome
Mouse	Spg7-Flox Strain Name：C57BL/6Smoc-Spg7^{em1(flox)Smoc} Strain State：Developing \| Cat. NO.：TBD
Mouse	Spg7-KO Strain Name：C57BL/6JSmo-Spg7^em1Smoc Strain State：Embryo Cryopreservation \| Cat. NO.：NM-KO-201075 Disease Connection：hereditary spastic paraplegia 7
Mouse	Sphk1-Flox Strain Name：C57BL/6JSmo-Sphk1^{em1(flox)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-CKO-210014
Mouse	Sphk1-KO Strain Name：C57BL/6JSmo-Sphk1^em1Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KO-191035 Research Application：Immune system, inflammation, anti-apoptosis, TNF-α signaling and NF-κB activation pathway
Mouse	Sphk2-Flox Strain Name：C57BL/6JSmo-Sphk2^{em1(flox)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-CKO-2104722
Mouse	Sphk2-KO Strain Name：C57BL/6JSmo-Sphk2^em1Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KO-191036 Research Application：Cell migration, proliferation and apoptosis; angiogenesis, tumorigenesis, cancer, breast cancer
Mouse	Sphkap-Flox Strain Name：C57BL/6Smoc-Sphkap^{em1(flox)Smoc} Strain State：Developing \| Cat. NO.：TBD
Mouse	Sphkap-KO Strain Name：C57BL/6Smoc-Sphkap^em1Smoc Strain State：Developing \| Cat. NO.：TBD

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