hALB

Nomenclature

C57BL/6JSmo-Albtm3(hALB)Smoc

Cat. NO.

NM-HU-200003

Strain State

Embryo Cryopreservation

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Gene Summary

Gene Symbol
ALB

Model Description

The endogenous mouse Alb gene was replaced by human ALB gene.
Research Application:Drug screening

Validation Data

1.png

图1. ELISA检测ALB人源化小鼠血清中hALB的表达情况。结果显示ALB人源化纯合子小鼠血清中可以检测到hALB的表达。

image.png

Fig.2 Detection of human ALB(A) and mouse ALB(B) expression in serum of WT C57BL/6 mice and HO hALB mice by ELISA. Human ALB was exclusively detectable in HO hALB mice. Mouse ALB was exclusively detectable in WT C57BL/6 mice. Serum were collected from wild-type C57BL/6 mice (n=3, male, 7 weeks old) and HO hALB mice (n=3, male, 7 weeks old), and analyzed by ELISA with anti-hALB ELISA kit and anti-mALB ELISA kit. 

Abbr.  HO, homozygous; WT, wild type; N.D. not detected.

image.png

Fig.3 Detection of human ALB expression in serum by ELISA. Human ALB was exclusively detectable in HO hALB, HO/HO hALB/hFCRN(2) and HO hALB(2) mice. Serum were collected from wild-type C57BL/6 mice and HO hALB, HO/HO hALB/hFCRN(2) and HO hALB(2) mice, and analyzed by ELISA with anti-hALB ELISA kit. 

Abbr.  HO, homozygous; WT, wild type; N.D. not detected.


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