Cd45.1

Nomenclature

C57BL/6JSmo-Ptprcem1(K302E)Smoc

Cat. NO.

NM-KI-210226

Strain State

Repository Live

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Gene Summary

Gene Symbol
Ptprc

Model Description

These mice carry a K302E mutation of Ptprc gene.

Validation Data

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Fig1. Analysis of CD45.1 expression on PBMC by FACS . The active expression of mCD45.1 was detected on PBMC.


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Fig2. Analysis of CD45.1 expression in the spleen by FACS . The active expression of mCD45.1 was detected in the spleen.

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Fig.3 Detection of CD45.1 expression on CD45+ cells in blood of WT C57BL/6 mice and CD45.1 mice by FACS. Leukocytes were collected from wild-type C57BL/6 mice (male, 8 weeks old) and HO CD45.1 mice (male, 8 weeks old), and analyzed by flow cytometry with anti-mCD45.1 and anti-CD45.2. CD45.1 was exclusively detectable on CD45+ cells in HO CD45.1 mice but not in wild-type mice, whereas CD45.2 was exclusively detectable on CD45+ cells in wild-type C57BL/6 mice but not in HO CD45.1 mice.


Publications 1piece

1. Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
Published year:2021-11-17 References:iScience

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