2210010C04Rik-D23A

Nomenclature

C57BL/6JSmo-2210010C04Rikem1D23ASmoc

Cat. NO.

NM-KI-232248

Strain State

Sperm cryopreservation

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Model Description

These strains carry a D23A mutation of 2210010C04Rik gene.

Validation Data

image.png

Fig 1. The pancreas of a heterozygous female mouse with RikD23A/+ mutation. 

Pancreatic tissue from 2-week-old and 23-week-old RikD23A/+ heterozygous female mice exhibited a loss of acinar cells, accompanied by infiltration of inflammatory cells, acinar-ductal metaplasia, fat infiltration, and fibrotic changes.The scale bar corresponds to 200 µm.


image.png

Pathology scores:0 represents within the normal range, 1 represents mild, 2 represents moderate, and 3 represents marked

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Fig 2. The pancreas of a heterozygous male mouse with RikD23A/+ mutation

Pancreatic tissue from 4-week-old and 8-week-old RikD23A/+ heterozygous male mice exhibited a loss of acinar cells, accompanied by infiltration of inflammatory cells, acinar-ductal metaplasia, fat infiltration, and fibrotic changes；The degree of fat infiltration and fibrosis is not significant in 2-week-old mice, and other phenotypes are mild.The scale bar corresponds to 200 µm.

image.png

Pathology scores:0 represents within the normal range, 1 represents mild, 2 represents moderate, and 3 represents marked


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