Prox1-IRES-CreERT2

Nomenclature

C57BL/6JSmo-Prox1em1(IRES-CreERT2-pA)Smoc

Cat. NO.

NM-KI-200119

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Prox1

Synonyms

A230003G05Rik

NCBI ID

19130

MGI ID

97772

Ensembl ID

ENSMUSG00000010175

Pubmed

Prox1

Human Ortholog

PROX1

Model Description

A IRES-CreERT2-pA expression cassette was knocked into the Prox1 gene stop codon site. Prox1 encodes a transcription factor (prospero-related homeobox 1) that is necessary for the formation and maintenance of lymphatic vessels. When Prox1-IRES-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in PROX1positive cells.
Research Application：Cre recombinase tool; Neuroscience

Validation Data

image.png

Fig1. CreERT2-mediated recombination in Dentate Gyrus of Prox1CreERT2/+;Rosa26tdTomato/+  mouse.image.png

Fig2. CreERT2-mediated recombination in Small intestine of Prox1CreERT2/+;Rosa26tdTomato/+ mouse. image.png

Fig3. Detection of tdTomato(red) in various tissues of Prox1CreERT2/+;Rosa26tdTomato/+ mice. Labeling was also observed in pituitary gland, retina, heart, thymus, stomach, lung, submandibular gland, muscle, ovary, spleen, pancreas and kidney. (For more information please contact: 400-728-0660.)

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more