Piezo1-CreERT2

Nomenclature

C57BL/6JSmo-Piezo1tm2(CreERT2)Smoc

Cat. NO.

NM-KI-18048

Strain State

Repository Live

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Gene Summary

Gene Symbol
Piezo1

Model Description

This tamoxifen-inducing Piezo1-CreERT2 tool mouse model was established by inserting a 2A-CreERT2 co-expression cassette into the Piezo1 gene stop codon site .
Research Application:Mechanically sensitive ion channel Cre tool mouse

Validation Data

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Fig1. Cre mediated recombination in lung of Piezo1 CreERT2/+;Rosa26 tdTomato/+ mice. 

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Fig2. Detection of tdTomato(red) in various tissues of Piezo1 CreERT2/+; Rosa26 tdTomato/+ mouse. 

After tamoxifen induction, tdTomato was expressed in the lung, large intestine, skeletal muscle, and skin. No obvious expression was detected in the brain, eye, heart, liver, stomach, salivary gland, adrenal gland, spinal cord, thymus, kidney, small intestine, spleen, reproductive system, prostate, or pancreas.

Mouse age:  Male, 50 days. (For more detailed information please contact our technical advisor.) 


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