hIL15RA
Nomenclature
C57BL/6JSmo-Il15ratm1(hIL15RA)Smoc
Cat. NO.
NM-HU-215070
Strain State
Repository Live
Gene Summary
Gene Symbol
Il15ra
Model Description
Validation Data
Fig.1 Detection of IL15RA expression in mammary gland and spleen by RT-PCR. Mouse Il15ra mRNA (120 bp) was detectable only in wild-type C57BL/6 mice. Human IL15RA mRNA (124 bp) was detectable only in homozygous hIL15RA knockin mice but not in wild-type mice. Mammary gland and spleen RNA was extracted from 6-week-old male wild-type C57BL/6 (WT)(n=2) and homozygous hIL15RA knockin mice (HO) (n=2), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mRNA primers.
Abbr. M, marker; HO, homozygous; WT, wild type.
Fig.2 Detection of hIL15RA expression on DC cells and Macrophage in BM of WT C57BL/6 mice and HO hIL15RA mice by FACS. hIL15RA was exclusively detectable in hIL15RA humanized mice but not in wild-type mice. hIL15RA was exclusively detectable on DC cells and Macrophage in hIL15RA humanized mice. Leukocytes were collected from wild-type C57BL/6 mice (female, 7 weeks old) and homozygous HO hIL15RA humanized mice (female, 7 weeks old),stimulated with LPS in vitro (1μg/mL), and analyzed by flow cytometry with anti-mIL15RA , anti-hIL15RA.
Abbr. HO, homozygous; WT, wild type.
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