hIGF2BP2
Nomenclature
C57BL/6JSmo-Igf2bp2tm1(hIGF2BP2)Smoc
Cat. NO.
NM-HU-251631
Strain State
Repository Live
Gene Summary
Gene Symbol
Igf2bp2
Model Description
Validation Data
Fig.1 Detection of IGF2BP2 expression in gonadal White Adipose Tissue(gWAT), pancreas and brain by RT-PCR. Mouse Igf2bp2 mRNA (224 bp) was detectable only in wild-type C57BL/6 mice. Human IGF2BP2 mRNA (159 bp) was detectable only in homozygous hIGF2BP2 knock-in mice but not in wild-type mice. Gonadal white adipose tissue (gWAT) and brain RNA was extracted from 6-week-old female wild-type C57BL/6 (n=2) and homozygous hIGF2BP2 knock-in mice (n=2), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mRNA primers.
Abbr. M, marker; HO, homozygous; WT, wild type.
Fig.2 Detection of human IGF2BP2 expression in hIGF2BP2 mice by IHC. IGF2BP2 protein was detectable in the liver, kidney, colon and cortex from WT mice and hIGF2BP2 knock-in mice using an antibody cross-reactive with both human and mouse IGF2BP2.
Tissues were collected from 9-week-old male WT C57BL/6 mice (n=3) and HO hIGF2BP2 mice (n=3), and then stained with anti-IGF2BP2 antibody. Black arrows indicate positive staining (brown). The scales are same in each image. Magnification, 20X.
Abbr. HO, homozygous; WT, wild type.
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