huHSC-(hIL3/hCSF2 NMG)

Nomenclature

huHSC-NOD.Cg-PrkdcscidIl2rgem1Tg(hIL3-hCSF2)Smoc

Cat. NO.

NM-HU-263008

Strain State

Repository Live

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Model Description

The cytokines IL-3 and GM-CSF are involved in the proliferation and differentiation of myeloid cell precursors. NMG mice transduced with the genes encoding IL-3 and GM-CSF can achieve myeloid cell reconstitution following human hematopoietic stem cell transplantation, presenting a more complete human immune system.

Validation Data

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Fig. 1 Human immune cell phenotyping in hIL3-hCSF2-transgenic (NMG) engrafted with human HSCs. Human CD34+ cells (1.0×10^5) were intravenously injected into homozygous hIL3-hCSF2-transgenic (NMG) pretreated with 1.0 Gy irradiation. These results demonstrate successful engraftment and propagation of human T, B, Myeloid and Momocytescells in the hIL3-hCSF2-transgenic (NMG) model.


For strain background verification data, refer to hIL3-hCSF2-Tg(NMG) NM-KI-215006. Click the link below for more details:

hIL3-hCSF2-Tg(NMG)-SMOC

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