Htr1a-KO

Nomenclature

C57BL/6JSmo-Htr1Aem1Smoc

Cat. NO.

NM-KO-190594

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Htr1a

Synonyms

Gpcr18

Chromosome

13

NCBI ID

15550

MGI ID

96273

Ensembl ID

ENSMUSG00000021721

Pubmed

Htr1a

Human Ortholog

HTR1A

Model Description

Exon 1 of Htr1a gene was deleted to generate Htr1a knockout mice.
Research Application：This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.

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