Hrh1-KO

Nomenclature

C57BL/6JSmo-Hrh1em1Smoc

Cat. NO.

NM-KO-190599

Strain State

Repository Live

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Gene Summary

Gene Symbol
Hrh1

Synonyms

H1R; Hir; Bphs; HH1R

NCBI ID

15465

MGI ID

107619

Ensembl ID

ENSMUSG00000053004

Pubmed

Hrh1

Human Ortholog

HRH1

Model Description

Exon 3 of Hrh1 gene was deleted to generate Hrh1 knockout mice.
Research Application：The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis.

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