Pml-KO

Nomenclature

C57BL/6JSmo-Pmlem1Smoc

Cat. NO.

NM-KO-190619

Strain State

Sperm cryopreservation

Export PDF

Gene Summary

Gene Symbol
Pml

Synonyms

Trim19; AI661194; 1200009E24Rik

NCBI ID

18854

MGI ID

104662

Ensembl ID

ENSMUSG00000036986

Pubmed

Pml

Human Ortholog

PML

Model Description

Exon 2 of Pml gene was deleted to generate Pml knockout mice.
Research Application：The protein encoded by this gene is a member of the tripartite motif (TRIM) family. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL).

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more