Lipa-KO

Nomenclature

C57BL/6JSmo-Lipaem1Smoc

Cat. NO.

NM-KO-201298

Strain State

Embryo Cryopreservation

Export PDF

Gene Summary

Gene Symbol
Lipa

Model Description

Exon 3 of Lipa gene was deleted to generate Lipa knockout mice.

Validation Data

image.png

Fig.1 Body weight of Lipa-KO and WT C57BL/6 mice. (2~4 month: n=3~6; 6 month: n=1~3)image.png

Fig.2 ALT and AST of Lipa-KO and WT C57BL/6 mice. (2~4 month: n=3~6; 6 month: n=1~3)

image.png

Fig.3 Blood lipid profile of Lipa-KO and WT C57BL/6 mice. (2~4 month: n=3~6; 6 month: n=1~3)

image.png

Fig.4 Cholesterol content of Lipa-KO and WT C57BL/6 mice in liver and spleen. (n=1~3).

image.png

Fig.5 Gross pathology and relative weight of liver of Lipa-KO and WT C57BL/6 mice. (n=1~3).

image.png

Fig. 6 Gross pathology and relative weight of spleen of Lipa-KO and WT C57BL/6 mice. (n=1~3).

image.png

Fig.7 Gross pathology and relative weight of small intestine of Lipa-KO and WT C57BL/6 mice. (n=1~3).

image.png

Fig.8 Relative weight of WAT of Lipa-KO and WT C57BL/6 mice. (n=1~3).

image.png

Fig.9 Representative oil‐red‐staining images of liver and spleen of of 3-month old mice Lipa-KO and WT C57BL/6 mice. 

image.png

Fig.10 Representative pictures of liver and spleen of 3-month old mice Lipa-KO and WT C57BL/6 mice. 

Macrophages (orange arrow), fibroblast proliferation (brown arrow), and granulocyte infiltration (red arrow).


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more

Workshop:Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

Learn more

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more