hIGF2BP2

Nomenclature

C57BL/6JSmo-Igf2bp2tm1(hIGF2BP2)Smoc

Cat. NO.

NM-HU-251631

Strain State

Repository Live

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Gene Summary

Gene Symbol
Igf2bp2

Model Description

The endogenous mouse Igf2bp2 gene was replaced by human IGF2BP2 gene.

Validation Data

image.png

Fig.1 Detection of IGF2BP2  expression in gonadal White Adipose Tissue(gWAT), pancreas and brain by RT-PCR. Mouse Igf2bp2 mRNA (224 bp) was detectable only in wild-type C57BL/6 mice. Human IGF2BP2 mRNA (159 bp) was detectable only in homozygous hIGF2BP2 knock-in mice but not in wild-type mice. Gonadal white adipose tissue (gWAT) and brain RNA was extracted from 6-week-old female wild-type C57BL/6 (n=2) and homozygous hIGF2BP2 knock-in mice (n=2), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mRNA primers. 

Abbr. M, marker; HO, homozygous; WT, wild type.


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