hCD3EDG/hBCMA
Nomenclature
C57BL/6JSmo-Tnfrsf17tm1(hBCMA)Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Smoc
Cat. NO.
NM-XA-253164
Strain State
Repository Live
Model Description
Validation Data
Fig.1 Detection of hBCMA expression on TACI+CD138+ cells in spleen and bone marrow of WT C57BL/6 mice and HO hCD3EDG/hBCMA mice by FACS. hBCMA was exclusively detectable in hCD3EDG/hBCMA humanized mice but not in wild-type mice. hBCMA was exclusively detectable on TACI+CD138+ cells in hBCMA humanized mice. Leukocytes were collected from wild-type C57BL/6 mice (female, 8 weeks old) and homozygous hCD3EDG/hBCMA humanized mice (female, 12 weeks old), and analyzed by flow cytometry with anti-hBCMA.
Abbr. HO, homozygous; WT, wild type.
Fig 2. In vivo efficacy study of teclistamab in HO hCD3EDG/hBCMA mice.
Teclistamab were injected at day 0, 3, 5, and immune cells in the spleen and bone marrow of mice after therapy were measured by flow cytometry (n=2). Values are shown as mean ± SEM.
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