hIGF1R(2)/hTFR1
Nomenclature
C57BL/6JSmo-Igf1rtm(hIGF1R)Tfrctm1(hTFRC)Smoc
Cat. NO.
NM-XA-253761
Strain State
Repository Live
Model Description
Validation Data
Fig.1 Detection of hIGF1R expression on CD45- cells in the brain of WT C57BL/6 mice and HO hIGF1R(2)/hTFR1 mice by FACS. hIGF1R was exclusively detectable in the brain of hIGF1R(2)/hTFR1 humanized mice but not in wild-type mice. CD45- cells were collected from wild-type C57BL/6 mice (male, 6-8 weeks old) and homozygous hIGF1R(2)/hTFR1 humanized mice (male, 7 weeks old), and analyzed by flow cytometry with anti-hCD221.
Abbr. HO, homozygous; WT, wild type.
Fig.2 Detection of hIGF1R expression on CD45- cells in the lung of WT C57BL/6 mice and HO hIGF1R(2)/hTFR1 mice by FACS. hIGF1R was exclusively detectable in the lung of hIGF1R(2)/hTFR1 humanized mice but not in wild-type mice. CD45- cells were collected from wild-type C57BL/6 mice (male, 6-8 weeks old) and homozygous hIGF1R(2)/hTFR1 humanized mice (male, 7 weeks old), and analyzed by flow cytometry with anti-hCD221.
Abbr. HO, homozygous; WT, wild type.
Fig.3 Detection of hTFR1 expression on CD45- cells in the brain of WT C57BL/6 mice and HO hIGF1R(2)/hTFR1 mice by FACS. hTFR1 was exclusively detectable in the brain of hIGF1R(2)/hTFR1 humanized mice but not in wild-type mice. CD45- cells were collected from wild-type C57BL/6 mice (male, 6-8 weeks old) and homozygous hIGF1R(2)/hTFR1 humanized mice (male, 7 weeks old), and analyzed by flow cytometry with anti-hCD71.
Abbr. HO, homozygous; WT, wild type.
Fig.4 Detection of hTFR1 expression on CD45- cells in the lung of WT C57BL/6 mice and HO hIGF1R(2)/hTFR1 mice by FACS. hTFR1 was exclusively detectable in the lung of hIGF1R(2)/hTFR1 humanized mice but not in wild-type mice. CD45- cells were collected from wild-type C57BL/6 mice (male, 6-8 weeks old) and homozygous hIGF1R(2)/hTFR1 humanized mice (male, 7 weeks old), and analyzed by flow cytometry with anti-hCD71.
Abbr. HO, homozygous; WT, wild type.
Fig.5 Detection of mTFR1 expression on CD45- cells in the brain of WT C57BL/6 mice and HO hIGF1R(2)/hTFR1 mice by FACS. mTFR1 was exclusively detectable in the brain of wild-type mice but not in hIGF1R(2)/hTFR1 humanized mice. CD45- cells were collected from wild-type C57BL/6 mice (male, 6-8 weeks old) and homozygous hIGF1R(2)/hTFR1 humanized mice (male, 7 weeks old), and analyzed by flow cytometry with anti-mCD71.
Abbr. HO, homozygous; WT, wild type.
Fig.6 Detection of mTFR1 expression on CD45- cells in the lung of WT C57BL/6 mice and HO hIGF1R(2)/hTFR1 mice by FACS. mTFR1 was exclusively detectable in the lung of wild-type mice but not in hIGF1R(2)/hTFR1 humanized mice. CD45- cells were collected from wild-type C57BL/6 mice (male, 6-8 weeks old) and homozygous hIGF1R(2)/hTFR1 humanized mice (male, 7 weeks old), and analyzed by flow cytometry with anti-mCD71.
Abbr. HO, homozygous; WT, wild type.
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