huHSC-(NVG-hIL15)

Nomenclature

huHSC-NOD-PrkdcscidIl2rgem1Il15(hIL15)Smoc

Cat. NO.

NM-HU-263007

Strain State

Repository Live

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Model Description

Interleukin-15 (IL-15) is essential for the activity, function, and differentiation of NK cells. The expression of human IL-15 in the severely immunodeficient NMG mouse background reduces the differences in immune environment between mice and humans, provides a more suitable survival environment for NK cells, and supports the reconstitution, expansion, and long-term expression of NK cells in vivo. In addition, NVG-hIL15 also supports the reconstitution and expansion of γδ T cells, enabling successful reconstitution with a relatively low injection dose of γδ T cells and extending the survival time of T cells.

Validation Data

image.png

Fig 1. Humanized immune reconstitution levels in huHSC-NVG-hIL15 mice. A. hCD45+ cell and mCD45+ cell in PB. B. hCD3+, hCD19+, hCD56+, hCD33+, hCD33+hCD14+, hCD33+ hCD66b+ cell in hCD45+ cell. 

For strain background verification data, refer to NVG-hIL15 GM-NVG-210001. Click the link below for

image.png

Fig. 1: Humanized immune reconstitution levels in huHSC-NVG-hIL15 mice. A. hCD45+ and mCD45+ cells in peripheral blood (PB). B. hCD3+, hCD19+, hCD56+, hCD33+, hCD33+, hCD14+, hCD33+, hCD66b+ cells in hCD45+ cells.

For strain background verification data, refer to NVG-hIL15GM-NVG-210001. Click the link below for more details: more details:

NVG-hIL15-SMOC

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