Alb-CreERT2

Nomenclature

B6.129S-Albtm1.1(CreERT2)Smoc

Cat. NO.

NM-KI-00002

Strain State

Repository Live

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Gene Summary

Gene Symbol
ALB

Synonyms

Alb1; Alb-1; BCL002

NCBI ID

11657

MGI ID

87991

Ensembl ID

ENSMUSG00000029368

Pubmed

ALB

Human Ortholog

ALB

Model Description

将CreERT2表达框定点敲入小鼠内源Alb基因ATG位置，建立Tamoxifen诱导的Alb-Cre工具鼠。该品系已去除Neo筛选基因。该小鼠是研究肝脏基因功能与疾病的重要小鼠品系。
Research Application：肝脏特异

Validation Data

alb-creERT2-1.png

Fig1 Alb-CreERT2; Rosa26-LacZ小鼠肝组织X-gal染色。未使用他莫昔芬诱导的小鼠，肝细胞未被染色；使用他莫昔芬诱导的小鼠，肝细胞成功着色，证明Alb-CreERT2小鼠可以成为实现肝脏时间特异性敲除或表达的工具鼠。

alb-creERT2-2.png

Fig2 Alb-CreERT2; Rosa26-LacZ小鼠肝组织免疫荧光检测。Alb-CreERT2; Rosa26-LacZ小鼠被他莫昔芬诱导后，LacZ（红色）表达，证明Alb-CreERT2小鼠可以成为实现肝脏时间特异性敲除或表达的工具鼠。


alb-creERT2-3.png


Fig3  Alb-CreERT2小鼠血生化检测。结果显示Alb-CreERT2小鼠与野生型小鼠相比肝功能正常。


Publications 28piece

1. Hepatocyte-to-intestinal stem cell remote communication regulates blood glucose homeostasis
Published year：2026 References：Cell Metabolism

2. Byakangelicin alleviates metabolic dysfunction-associated steatohepatitis by selective inhibition of a non-canonical MTORC1 signaling pathway
Published year：2026 References：Autophagy

3. Loss of hepatic ME1 ameliorates MASLD by Suppressing peroxisomal β-Oxidation and Activating Lipophagy/Lipolysis
Published year：2025 References：Journal of Advanced Research

4. Elevated plasma levels of alpha-synuclein are dispensable for Parkinson’s disease pathology
Published year：2025 References：npj Parkinsons Disease

5. LGR4 is a key regulator of hepatic gluconeogenesis
Published year：2025 References：FREE RADICAL BIOLOGY AND MEDICINE

6. Zinc finger BED-type containing 3 promotes hepatic steatosis by interacting with polypyrimidine tract-binding protein 1
Published year：2024 References：DIABETOLOGIA

7. Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Published year：2024 References：INFLAMMATION RESEARCH

8. AHR regulates liver enlargement and regeneration through the YAP signaling pathway
Published year：2024 References：Heliyon

9. Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
Published year：2023 References：NEURON

10. Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury
Published year：2023 References：Autophagy

11. Mitochondria-derived H2O2 triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice
Published year：2023 References：Cell Death & Disease

12. PPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit progression of hepatocellular carcinoma
Published year：2023 References：Molecular Therapy-Nucleic Acids

13. Hepatocyte CD36 protects mice from NASH diet-induced liver injury and fibrosis via blocking N1ICD production
Published year：2023 References：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

14. Hepatic Nampt Deficiency Aggravates Dyslipidemia and Fatty Liver in High Fat Diet Fed Mice
Published year：2023 References：Cells

15. Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway
Published year：2023 References：Nutrients

16. CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice
Published year：2023 References：iScience

17. Mitochondrial fragmentation is crucial for c-Myc-driven hepatoblastoma-like liver tumors
Published year：2022 References：MOLECULAR THERAPY

18. Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine–Induced Acute Liver Failure Through Inhibiting GSK3β–Nrf2–Mediated Hepatocyte Apoptosis and Ferroptosis
Published year：2022 References：Cellular and Molecular Gastroenterology and Hepatology

19. Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response
Published year：2021 References：Aging-US

20. Mesencephalic astrocyte-derived neurotrophic factor alleviates alcohol induced hepatic steatosis via activating Stat3-mediated autophagy
Published year：2021 References：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

21. Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride
Published year：2020 References：ACTA PHARMACOLOGICA SINICA

22. STAT3 and AKT signaling pathways mediate oncogenic role of NRSF in hepatocellular carcinoma
Published year：2020 References：ACTA BIOCHIMICA ET BIOPHYSICA SINICA

23. HDAC3 Deficiency Promotes Liver Cancer through a Defect in H3K9ac/H3K9me3 Transition
Published year：2019 References：CANCER RESEARCH

24. Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress
Published year：2019 References：Cell Reports

25. Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway
Published year：2018 References：Cell Death & Disease

26. Enhancing the precision of genetic lineage tracing using dual recombinases
Published year：2017 References：NATURE MEDICINE

27. Fate tracing of hepatocytes in mouse liver
Published year：2017 References：Scientific Reports

28. SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma
Published year：2016 References：Oncotarget

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Reference(s)

Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress
References：Cell Reports

Fate tracing of hepatocytes in mouse liver
References：SCIENTIFIC REPORTS

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