Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

Mouse	Raf1-D486N Strain Name：C57BL/6JSmo-Raf1^{em1(D486N)Smoc} Strain State：Embryo Cryopreservation \| Cat. NO.：NM-KI-200252 Research Application：Noonan syndrome
Mouse	Ripk1-D138N Strain Name：C57BL/6JSmo-Ripk1^{em1(D138N)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-200280
Mouse	Ryr1-R4884C Strain Name：C57BL/6JSmo-Ryr1^{em(R4884C)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-225075
Mouse	Ryr2-R1760W Strain Name：C57BL/6JSmo-Ryr2^{tm1(R1760W)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-230112
Mouse	Scn1a-c.473+5G>A Strain Name：C57BL/6JSmo-Scn1a^{em1(c.473+5G>A)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-210417
Mouse	Setx-P1674L Strain Name：C57BL/6JSmo-Setx^em1(P1674L)^Smoc Strain State：Developing \| Cat. NO.：NM-KI-232087
Mouse	Slc6a1-S295L Strain Name：C57BL/6JSmo-Slc6a1^{em2(S295L)Smoc} Strain State：Repository Live \| Cat. NO.：NM-KI-190014 Research Application：Nervous system, Immune system, Genetic epilepsy, Rare disease
Mouse	Sod1-G94A Strain Name：C57BL/6JSmo-Sod1^em1(G94A)^Smoc Strain State：Repository Live \| Cat. NO.：NM-KI-232083
Mouse	Spink1-c.197+2t>c Strain Name：C57BL/6JSmo-Spink1^{em1c.197+2t>c}^Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-232249
Mouse	Tardbp-M337V Strain Name：C57BL/6JSmo-Tardbp^em1(M337V)^Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-232085

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