Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

Mouse	Kras-RSR-G12D Strain Name：C57BL/6JSmo-Kras^{tm(Rox-Stop-Rox-G12D)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-210436
Mouse	Lat-Y136F Strain Name：C57BL/6JSmo-Lat^{em1(Y136F）Smoc} Strain State：Repository Live \| Cat. NO.：NM-KI-200249 Disease Connection：IgG4-related disease
Mouse	Ldlr-C223R Strain Name：C57BL/6JSmo-Ldlr^{em1(C223R)Smoc} Strain State：Embryo Cryopreservation \| Cat. NO.：NM-KI-00043 Research Application：Metabolic and cardiovascular disease research
Mouse	Lep-R105X Strain Name：C57BL/6JSmo-Lep^{em(R105X)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-230475
Mouse	Lep-R105X(BALB/c) Strain Name：BALB/cJSmo-Lep^{em(R105X)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-230476
Mouse	Lepr-g.G109052T Strain Name：B6.129S-Lepr^tm1Smoc Strain State：Embryo Cryopreservation \| Cat. NO.：NM-KI-00001 Research Application：Leptin resistance,insulin resistance,obesity,and type 2 diabetes etc.
Mouse	Lmna-c.C1827T Strain Name：C57BL/6JSmo-Lmna^{tm1(G609G)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-200284 Disease Connection：progeria
Mouse	Lrrk2-P1446L Strain Name：C57BL/6JSmo-Lrrk2^{em(P1446L)Smoc} Strain State：Embryo Cryopreservation \| Cat. NO.：NM-KI-215098
Mouse	Mapt-R5H Strain Name：C57BL/6JSmo-Mapt^em(R5H)Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-215099
Mouse	Mcm7-R43Q Strain Name：C57BL/6JSmo-Mcm7^em1R43Q^Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KI-233284

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